ITT0650
ITT0650
- Catalog: ITT0650
- Gene/Protein: CSNK1D
- Product Description: Immunotag™ Casein Kinase Iδ Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Casein Kinase Iδ |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Casein Kinase Iδ, at AA range: 260-340 |
| Specificity | Casein Kinase Iδ Polyclonal Antibody detects endogenous levels of Casein Kinase Iδ protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CSNK1D |
| Accession No. | P48730 Q9DC28 Q06486 |
| Alternate Names | CSNK1D; HCKID; Casein kinase I isoform delta; CKI-delta; CKId; Tau-protein kinase CSNK1D |
| Description | casein kinase 1 delta(CSNK1D) Homo sapiens This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014], |
| Cell Pathway/ Category | Hedgehog,Gap junction,Circadian rhythm, |
| Protein Expression | Brain,Epithelium,Hematopoietic stem cell,Placenta,Spleen, |
| Subcellular Localization | Golgi membrane,nucleus,nucleoplasm,Golgi apparatus,centrosome,spindle,cytosol,spindle microtubule,plasma membrane,cell-cell adherens junction,endoplasmic reticulum-Golgi intermediate compartment membrane,neuron projection, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.,enzyme regulation:Exhibits substrate-dependent heparin activation.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.,PTM:Autophosphorylated on serine and threonine residues.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation.,tissue specificity:Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopioetic cells and mature granulocytes. Also found in monocytes and lymphocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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