ITT0688
ITT0688
- Catalog: ITT0688
- Gene/Protein: CNR2
- Product Description: Immunotag™ CB2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CB2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CNR2. AA range:191-240 |
| Specificity | CB2 Polyclonal Antibody detects endogenous levels of CB2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CNR2 |
| Accession No. | P34972 P47936 |
| Alternate Names | CNR2; Cannabinoid receptor 2; CB-2; CB2; hCB2; CX5 |
| Description | cannabinoid receptor 2(CNR2) Homo sapiens The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | Blood,Brain, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,integral component of membrane,dendrite,extrinsic component of cytoplasmic side of plasma membrane,neuronal cell body,perikaryon, |
| Protein Function | disease:Allelic variation at the CB2 locus is associated to genetic predisposition for depression in Japanese populations.,function:Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.,PTM:Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localizes to apical dendrite of pyramidal neurons.,tissue specificity:Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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