ITT0734
ITT0734
- Catalog: ITT0734
- Gene/Protein: IGLL1/IGLC1/IGLC2/IGLC3/IGLC6/IGLC7
- Product Description: Immunotag™ CD179b Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | CD179b |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CD179b. AA range:26-75 |
| Specificity | CD179b Polyclonal Antibody detects endogenous levels of CD179b protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | IGLL1/IGLC1/IGLC2/IGLC3/IGLC6/IGLC7 |
| Accession No. | P15814/P0CG04/P0CG05/P0CG06/P0CF74/A0M8Q6 |
| Alternate Names | IGLL1; IGL1; Immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD antigen CD179b; IGLC1; Ig lambda-1 chain C regions; IGLC2; Ig |
| Description | immunoglobulin lambda like polypeptide 1(IGLL1) Homo sapiens The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Primary immunodeficiency, |
| Protein Expression | Lymphoid,Testis, |
| Subcellular Localization | external side of plasma membrane,membrane,immunoglobulin complex, circulating,extracellular exosome,blood microparticle, |
| Protein Function | disease:Defects in IGLL1 are a cause of autosomal recessive non-Bruton type agammaglobulinemia [MIM:601495]. It is characterized by agammaglobulinemia and markedly reduced numbers of B cells.,online information:IGLL1 mutation db,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Associates non-covalently with VPREB1.,tissue specificity:Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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