ITT0750
ITT0750
- Catalog: ITT0750
- Gene/Protein: TNFSF8
- Product Description: Immunotag™ CD30-L Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD30-L |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CD153. AA range:71-120 |
| Specificity | CD30-L Polyclonal Antibody detects endogenous levels of CD30-L protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TNFSF8 |
| Accession No. | P32971 P32972 |
| Alternate Names | TNFSF8; CD30L; CD30LG; Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; CD antigen CD153 |
| Description | tumor necrosis factor superfamily member 8(TNFSF8) Homo sapiens The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction, |
| Protein Expression | Brain,Thymus, |
| Subcellular Localization | extracellular space,integral component of plasma membrane,integral component of membrane, |
| Protein Function | function:Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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