ITT0837
ITT0837
- Catalog: ITT0837
- Gene/Protein: CDK5RAP2
- Product Description: Immunotag™ CDK5 Activator-binding C48 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CDK5 AB C48 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDK5RAP2. AA range:251-300 |
| Specificity | CDK5 Activator-binding C48 Polyclonal Antibody detects endogenous levels of CDK5 Activator-binding C48 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CDK5RAP2 |
| Accession No. | Q96SN8 Q8K389 |
| Alternate Names | CDK5RAP2; CEP215; KIAA1633; CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48; Centrosome-associated protein 215 |
| Description | CDK5 regulatory subunit associated protein 2(CDK5RAP2) Homo sapiens This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013], |
| Protein Expression | Amygdala,Brain,Endometrium carcinoma cell line,Epithelium,H |
| Subcellular Localization | pericentriolar material,spindle pole,cytoplasm,Golgi apparatus,centrosome,microtubule organizing center,cytosol,cytoskeleton,microtubule,integral component of membrane,cell junction,microtubule plus-end,G |
| Protein Function | disease:Defects in CDK5RAP2 are the cause of primary microcephaly autosomal recessive type 3 (MCPH3) [MIM:604804]. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits.,function:Potential regulator of CDK5 activity via its interaction with CDK5R1.,miscellaneous:The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.,PTM:Phosphorylated in vitro by CDK5.,sequence caution:Translated as Gln.,subunit:Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5.,tissue specificity:Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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