ITT0858
ITT0858
- Catalog: ITT0858
- Gene/Protein: CEP170
- Product Description: Immunotag™ CEP170 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CEP18000 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CEP170. AA range:701-750 |
| Specificity | CEP170 Polyclonal Antibody detects endogenous levels of CEP170 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CEP170 |
| Accession No. | Q5SW79 Q6A065 |
| Alternate Names | CEP170; FAM68A; KAB; KIAA0470; Centrosomal protein of 170 kDa; Cep170; KARP-1-binding protein; KARP1-binding protein |
| Description | centrosomal protein 170(CEP170) Homo sapiens The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Cervix carcinoma,Epithelium,Skin,Testis, |
| Subcellular Localization | cytoplasm,centrosome,centriole,spindle,microtubule,integral component of membrane,nuclear membrane, |
| Protein Function | function:Plays a role in microtubule organization.,PTM:Phosphorylated; probably by PLK1. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CEP170 family.,similarity:Contains 1 FHA domain.,subcellular location:Associated with the mature mother centriole. Associated with spindle microtubules during mitosis.,subunit:Interacts with PLK1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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