ITT0874
ITT0874
- Catalog: ITT0874
- Gene/Protein: CES2
- Product Description: Immunotag™ CES2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CES2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human CES2. |
| Specificity | CES2 Polyclonal Antibody detects endogenous levels of CES2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CES2 |
| Accession No. | O00748 |
| Alternate Names | CES2; ICE; Cocaine esterase; Carboxylesterase 2; CE-2; hCE-2; Methylumbelliferyl-acetate deacetylase 2 |
| Description | carboxylesterase 2(CES2) Homo sapiens This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010], |
| Cell Pathway/ Category | Drug metabolism, |
| Protein Expression | Colon,Endometrial adenocarcinoma,Liver,Skin,Small intestine,Testis, |
| Subcellular Localization | extracellular space,endoplasmic reticulum,endoplasmic reticulum lumen,extracellular exosome, |
| Protein Function | catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.,PTM:Glycosylated.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Monomer.,tissue specificity:Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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