ITT0956
ITT0956
- Catalog: ITT0956
- Gene/Protein: CLDN7
- Product Description: Immunotag™ Claudin-7 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Claudin-7 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Claudin-7, at AA range: 140-220 |
| Specificity | Claudin-7 Polyclonal Antibody detects endogenous levels of Claudin-7 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CLDN7 |
| Accession No. | O95471 Q9Z261 Q9Z1L1 |
| Alternate Names | CLDN7; CEPTRL2; CPETRL2; Claudin-7; CLDN-7 |
| Description | claudin 7(CLDN7) Homo sapiens This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration, |
| Protein Expression | Colon,Colon adenocarcinoma,Mammary gland,Placenta, |
| Subcellular Localization | plasma membrane,bicellular tight junction,integral component of membrane,basolateral plasma membrane,apicolateral plasma membrane,lateral plasma membrane, |
| Protein Function | function:Plays a major role in tight junction-specific obliteration of the intercellular space.,induction:By androgens.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,tissue specificity:Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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