ITT1061
ITT1061
- Catalog: ITT1061
- Gene/Protein: CORO1A
- Product Description: Immunotag™ Coronin 1A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Coronin 1A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Coronin 1A, at AA range: 150-230 |
| Specificity | Coronin 1A Polyclonal Antibody detects endogenous levels of Coronin 1A protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CORO1A |
| Accession No. | P31146 O89053 Q91ZN1 |
| Alternate Names | CORO1A; CORO1; Coronin-1A; Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO |
| Description | coronin 1A(CORO1A) Homo sapiens This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010], |
| Protein Expression | Brain,Hippocampus,Keratinocyte,Kidney,Peripheral blood leukocyte,T-cell, |
| Subcellular Localization | immunological synapse,phagocytic cup,nucleus,cytoplasm,early endosome,cytosol,actin filament,plasma membrane,cell-cell junction,actin cytoskeleton,membrane,lamellipodium,axon,phagocytic vesicle membrane, |
| Protein Function | function:May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.,similarity:Belongs to the WD repeat coronin family.,similarity:Contains 5 WD repeats.,subcellular location:In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.,subunit:Binds actin.,tissue specificity:Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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