ITT1094
ITT1094
- Catalog: ITT1094
- Gene/Protein: CRABP2
- Product Description: Immunotag™ CRABP-II Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CRABP-II |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from CRABP-II, at AA range: 10-90 |
| Specificity | CRABP-II Polyclonal Antibody detects endogenous levels of CRABP-II protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CRABP2 |
| Accession No. | P29373 P22935 P51673 |
| Alternate Names | CRABP2; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II |
| Description | cellular retinoic acid binding protein 2(CRABP2) Homo sapiens This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010], |
| Protein Expression | Colon,Placenta, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,endoplasmic reticulum,cytosol,extracellular exosome, |
| Protein Function | domain:Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.,function:Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.,induction:By retinoic acid.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,subcellular location:Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.,subunit:Interacts with RXR and RARA (By similarity). Interacts with importin alpha., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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