ITT1232
ITT1232
- Catalog: ITT1232
- Gene/Protein: CYP4A11/CYP4A22
- Product Description: Immunotag™ CYP4A11/22 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CYP4A11/22 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Cytochrome P450 4A11/22. AA range:391-440 |
| Specificity | CYP4A11/22 Polyclonal Antibody detects endogenous levels of CYP4A11/22 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CYP4A11/CYP4A22 |
| Accession No. | Q02928/Q5TCH4 |
| Alternate Names | CYP4A11; CYP4A2; Cytochrome P450 4A11; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase; CYP4A22; C |
| Description | cytochrome P450 family 4 subfamily A member 11(CYP4A11) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016], |
| Cell Pathway/ Category | Fatty acid metabolism,Arachidonic acid metabolism,Retinol metabolism,PPAR,Vascular smooth muscle contraction, |
| Protein Expression | Colon,Kidney,Liver, |
| Subcellular Localization | cytoplasm,endoplasmic reticulum membrane,integral component of membrane,apical plasma membrane,organelle membrane,intracellular membrane-bounded organelle,extracellular exosome, |
| Protein Function | catalytic activity:Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O.,cofactor:Heme group.,function:Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).,online information:CYP4A11 alleles,polymorphism:CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Kidney and liver., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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