ITT1356
ITT1356
- Catalog: ITT1356
- Gene/Protein: DLC1
- Product Description: Immunotag™ DLC-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DLC-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,IF,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from DLC-1, at AA range: 30-110 |
| Specificity | DLC-1 Polyclonal Antibody detects endogenous levels of DLC-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | DLC1 |
| Accession No. | Q96QB1 Q9R0Z9 Q63744 |
| Alternate Names | DLC1; ARHGAP7; KIAA1723; STARD12; Rho GTPase-activating protein 7; Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein |
| Description | DLC1 Rho GTPase activating protein(DLC1) Homo sapiens This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010], |
| Protein Expression | Brain,Heart,Lung,Trachea, |
| Subcellular Localization | nucleus,cytoplasm,cytosol,caveola,focal adhesion,cortical actin cytoskeleton,ruffle membrane, |
| Protein Function | function:Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization.,sequence caution:Chimera. Sequence from position 1 to 13 is due to a chimera.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 1 START domain.,tissue specificity:Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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