ITT1365
ITT1365
- Catalog: ITT1365
- Gene/Protein: LIG3
- Product Description: Immunotag™ DNA Ligase III Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DNA Ligase III |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from DNA Ligase III . at AA range: 110-190 |
| Specificity | DNA Ligase III Polyclonal Antibody detects endogenous levels of DNA Ligase III protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | LIG3 |
| Accession No. | P49916 P97386 |
| Alternate Names | LIG3; DNA ligase 3; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3 |
| Description | DNA ligase 3(LIG3) Homo sapiens This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Base excision repair, |
| Protein Expression | Brain,Epithelium,Prostate,Testis, |
| Subcellular Localization | nucleus,nucleoplasm,mitochondrion,DNA ligase III-XRCC1 complex, |
| Protein Function | catalytic activity:ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).,cofactor:Magnesium.,function:Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,online information:DNA ligase entry,similarity:Belongs to the ATP-dependent DNA ligase family.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP-type zinc finger.,tissue specificity:Testis, thymus, prostate and heart., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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