ITT1373
ITT1373
- Catalog: ITT1373
- Gene/Protein: POLE4
- Product Description: Immunotag™ DNA pol ε 4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DNA pol ε 4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human POLE4. AA range:61-110 |
| Specificity | DNA pol ε 4 Polyclonal Antibody detects endogenous levels of DNA pol ε 4 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | POLE4 |
| Accession No. | Q9NR33 Q9CQ36 |
| Alternate Names | POLE4; DNA polymerase epsilon subunit 4; DNA polymerase II subunit 4; DNA polymerase epsilon subunit p12 |
| Description | DNA polymerase epsilon 4, accessory subunit(POLE4) Homo sapiens POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004], |
| Cell Pathway/ Category | Purine metabolism,Pyrimidine metabolism,DNA replication,Base excision repair,Nucleotide excision repair, |
| Protein Expression | Cervix carcinoma,Skin, |
| Subcellular Localization | nucleus,Ada2/Gcn5/Ada3 transcription activator complex,epsilon DNA polymerase complex, |
| Protein Function | catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,function:May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Consists of four subunits: POLE1, POLE2, POLE3 and POLE4. Interacts with POLE3. When bound to POLE3, it can associate with polymerase epsilon p261 and p59 and form a complex., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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