ITT1374
ITT1374
- Catalog: ITT1374
- Gene/Protein: POLE
- Product Description: Immunotag™ DNA pol ε A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DNA pol ε A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human POLE1. AA range:1261-1310 |
| Specificity | DNA pol ε A Polyclonal Antibody detects endogenous levels of DNA pol ε A protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | POLE |
| Accession No. | Q07864 Q9WVF7 |
| Alternate Names | POLE; POLE1; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit A |
| Description | DNA polymerase epsilon, catalytic subunit(POLE) Homo sapiens This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013], |
| Cell Pathway/ Category | Purine metabolism,Pyrimidine metabolism,DNA replication,Base excision repair,Nucleotide excision repair, |
| Protein Expression | Aorta endothelial cell,Colon,Kidney,Lung,T-cell,Testis, |
| Subcellular Localization | nucleus,nucleoplasm,plasma membrane,epsilon DNA polymerase complex, |
| Protein Function | catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,domain:The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme.,function:Participates in DNA repair and in chromosomal DNA replication.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA polymerase type-B family.,subunit:Consists of two subunits (258 kDa and 55 kDa). Interacts with RAD17 and TOPBP1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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