ITT1424
ITT1424
- Catalog: ITT1424
- Gene/Protein: DVL2
- Product Description: Immunotag™ Dvl-2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Dvl-2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Dvl-2 . at AA range: 670-750 |
| Specificity | Dvl-2 Polyclonal Antibody detects endogenous levels of Dvl-2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | DVL2 |
| Accession No. | O14641 Q60838 |
| Alternate Names | DVL2; Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2 |
| Description | dishevelled segment polarity protein 2(DVL2) Homo sapiens This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | WNT,WNT-T CELLNotch,Melanogenesis,Pathways in cancer,Colorectal cancer,Basal cell carcinoma, |
| Protein Expression | Colon, |
| Subcellular Localization | intracellular,nucleus,cytoplasm,cytosol,plasma membrane,lateral plasma membrane,cytoplasmic vesicle,apical part of cell,clathrin-coated endocytic vesicle, |
| Protein Function | function:May play a role in the signal transduction pathway mediated by multiple Wnt genes.,PTM:Phosphorylated.,similarity:Belongs to the DSH family.,similarity:Contains 1 DEP domain.,similarity:Contains 1 DIX domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts with DIXDC1 and Rac., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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