ITT1430
ITT1430
- Catalog: ITT1430
- Gene/Protein: DNAI2
- Product Description: Immunotag™ Dynein IC2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Dynein IC2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Dynein IC2, at AA range: 40-120 |
| Specificity | Dynein IC2 Polyclonal Antibody detects endogenous levels of Dynein IC2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | DNAI2 |
| Accession No. | Q9GZS0 A2AC93 Q66HC9 |
| Alternate Names | DNAI2; Dynein intermediate chain 2; axonemal; Axonemal dynein intermediate chain 2 |
| Description | dynein axonemal intermediate chain 2(DNAI2) Homo sapiens The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010], |
| Cell Pathway/ Category | Huntington's disease, |
| Protein Expression | Brain,Testis, |
| Subcellular Localization | cytoplasm,axonemal dynein complex,microtubule,axoneme,external side of plasma membrane,sperm flagellum,outer dynein arm, |
| Protein Function | disease:Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.,function:Part of the dynein complex of respiratory cilia.,sequence caution:Intron retention.,similarity:Belongs to the dynein intermediate chain family.,similarity:Contains 5 WD repeats.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with KTU.,tissue specificity:Highly expressed in trachea and testis., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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