ITT1530
ITT1530
- Catalog: ITT1530
- Gene/Protein: ELL
- Product Description: Immunotag™ ELL Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ELL |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ELL. AA range:91-140 |
| Specificity | ELL Polyclonal Antibody detects endogenous levels of ELL protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ELL |
| Accession No. | P55199 O08856 |
| Alternate Names | ELL; C19orf17; RNA polymerase II elongation factor ELL; Eleven-nineteen lysine-rich leukemia protein |
| Description | disease:A chromosomal translocation involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.,function:Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ELL/occludin family.,subcellular location:Colocalizes with EAF2 to nuclear speckles. Also localized to Cajal (coiled) bodies.,subunit:Interacts with EAF1 and EAF2.,tissue specificity:Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes., |
| Protein Expression | Brain,Epithelium,Fetal brain, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,plasma membrane,transcription elongation factor complex,Cajal body,actin cytoskeleton,nuclear speck,transcriptionally active chromatin,histone locus body, |
| Protein Function | disease:A chromosomal translocation involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.,function:Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ELL/occludin family.,subcellular location:Colocalizes with EAF2 to nuclear speckles. Also localized to Cajal (coiled) bodies.,subunit:Interacts with EAF1 and EAF2.,tissue specificity:Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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