ITT1541
ITT1541
- Catalog: ITT1541
- Gene/Protein: EME1
- Product Description: Immunotag™ Eme1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Eme1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Eme1 . at AA range: 250-330 |
| Specificity | Eme1 Polyclonal Antibody detects endogenous levels of Eme1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | EME1 |
| Accession No. | Q96AY2 Q8BJW7 |
| Alternate Names | EME1; MMS4; Crossover junction endonuclease EME1; MMS4 homolog; hMMS4 |
| Description | essential meiotic structure-specific endonuclease 1(EME1) Homo sapiens This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009], |
| Cell Pathway/ Category | Homologous recombination, |
| Protein Expression | Epithelium,Placenta, |
| Subcellular Localization | nuclear chromatin,nucleus,nucleoplasm,nuclear heterochromatin,nucleolus,cytoplasm,Holliday junction resolvase complex, |
| Protein Function | cofactor:Magnesium.,function:Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.,similarity:Belongs to the EME1/MMS4 family.,subcellular location:Recruited to regions of DNA damage in S-phase cells.,subunit:May self-associate. Interacts with MUS81. Interacts with ERCC4 and FANCM., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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