ITT1543
ITT1543
- Catalog: ITT1543
- Gene/Protein: MAEA
- Product Description: Immunotag™ Emp Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | EMP |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Emp, at AA range: 150-230 |
| Specificity | Emp Polyclonal Antibody detects endogenous levels of Emp protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MAEA |
| Accession No. | Q7L5Y9 Q4VC33 Q5RKJ1 |
| Alternate Names | MAEA; EMP; HLC10; PIG5; Macrophage erythroblast attacher; Cell proliferation-inducing gene 5 protein; Erythroblast macrophage protein; Human lung cancer oncogene 10 protein; HLC-10 |
| Description | macrophage erythroblast attacher(MAEA) Homo sapiens This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014], |
| Protein Expression | Embryo,Lung,Spleen,Thymus, |
| Subcellular Localization | nucleus,cytoplasm,spindle,actomyosin contractile ring,cytoskeleton,integral component of plasma membrane,nuclear matrix,GID complex, |
| Protein Function | developmental stage:Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis.,function:Play a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.,similarity:Contains 1 CTLH domain.,similarity:Contains 1 LisH domain.,subcellular location:Localized as nuclear speckled-like pattern.,subunit:Form a complex with F-actin.,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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