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ITT1570

ITT1570-2
ITT1570
ITT1570-2
ITT1570
ITT1570
  • Gene/Protein: PTGER4
  • Product Description: Immunotag™ EP4 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ EP4 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein EP4
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IF,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human PE2R4. AA range:321-370
Specificity EP4 Polyclonal Antibody detects endogenous levels of EP4 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name PTGER4
Accession No. P35408 P32240
Alternate Names PTGER4; PTGER2; Prostaglandin E2 receptor EP4 subtype; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostanoid EP4 receptor
Description prostaglandin E receptor 4(PTGER4) Homo sapiens The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Neuroactive ligand-receptor interaction,
Protein Expression Brain,Lung,
Subcellular Localization intracellular,plasma membrane,integral component of plasma membrane,integral component of membrane,
Protein Function caution:Was originally designated as the EP2 subtype.,function:Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with FEM1A.,tissue specificity:High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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