ITT1595
ITT1595
- Catalog: ITT1595
- Gene/Protein: EFNB1/EFNB2
- Product Description: Immunotag™ Ephrin-B1/2 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | EPHrin-B1/2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from Ephrin-B1/2, at AA range: 270-350 |
Specificity | Ephrin-B1/2 Polyclonal Antibody detects endogenous levels of Ephrin-B1/2 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | EFNB1/EFNB2 |
Accession No. | P98172/P52799 P52796 |
Alternate Names | EFNB1; EFL3; EPLG2; LERK2; Ephrin-B1; EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; EFNB2; EPLG5; HTKL; LERK5; Ephrin-B2; EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L |
Description | ephrin B1(EFNB1) Homo sapiens The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008], |
Cell Pathway/ Category | Axon guidance, |
Protein Expression | Eye,Fetal brain,Placenta,Skin, |
Subcellular Localization | nucleus,cytoplasm,plasma membrane,integral component of plasma membrane,membrane raft,synapse,extracellular exosome, |
Protein Function | disease:Defects in EFNB1 are a cause of craniofrontonasal syndrome (CFNS) [MIM:304110]; also known as craniofrontonasal dysplasia (CFND). CFNS is an X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies.,function:Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.,induction:By TNF-alpha.,PTM:Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.,similarity:Belongs to the ephrin family.,subunit:Interacts with GRIP1 and GRIP2.,tissue specificity:Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |