ITT1602
ITT1602
- Catalog: ITT1602
- Gene/Protein: EPN2
- Product Description: Immunotag™ Epsin 2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | EPSin 2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Epsin 2, at AA range: 240-320 |
| Specificity | Epsin 2 Polyclonal Antibody detects endogenous levels of Epsin 2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | EPN2 |
| Accession No. | O95208 Q8CHU3 Q9Z1Z3 |
| Alternate Names | EPN2; KIAA1065; Epsin-2; EPS-15-interacting protein 2 |
| Description | epsin 2(EPN2) Homo sapiens This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Endocytosis, |
| Protein Expression | Brain,Embryo,Epithelium,Placenta,Testis, |
| Subcellular Localization | nucleoplasm,Golgi apparatus,cell-cell adherens junction,clathrin coat of endocytic vesicle,intracellular membrane-bounded organelle, |
| Protein Function | caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:The DPW repeat domain is involved in AP-2 and clathrin binding.,domain:The NPF repeat domain is involved in EPS15 binding.,function:Plays a role in the formation of clathrin-coated invaginations and endocytosis.,PTM:Ubiquitinated.,similarity:Belongs to the epsin family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,subcellular location:In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.,subunit:Binds EPS15 (By similarity). Binds AP-2 and clathrin.,tissue specificity:Highest expression is found in brain. Detected at lower levels in lung and liver., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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