ITT1679
ITT1679
- Catalog: ITT1679
- Gene/Protein: FOXH1
- Product Description: Immunotag™ FAST-1/2 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | FAST-1/2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IF,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from human FOXH1. AA range:10-59 |
Specificity | FAST-1/2 Polyclonal Antibody detects endogenous levels of FAST-1/2 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | FOXH1 |
Accession No. | O75593 O88621 |
Alternate Names | FOXH1; FAST1; FAST2; Forkhead box protein H1; Forkhead activin signal transducer 1; Fast-1; hFAST-1; Forkhead activin signal transducer 2; Fast-2 |
Description | forkhead box H1(FOXH1) Homo sapiens FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008], |
Protein Expression | Colon adenocarcinoma,Ovary, |
Subcellular Localization | nuclear chromatin,nucleus,nucleoplasm,transcription factor complex,activin responsive factor complex, |
Protein Function | domain:The FM region is required for binding smad2/smad4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated smad2 that is in an activated smad complex.,function:Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with the MH2 domains of SMAD2 and SMAD3.,tissue specificity:Ubiquitous., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |