ITT1692
ITT1692
- Catalog: ITT1692
- Gene/Protein: FTH1
- Product Description: Immunotag™ Ferritin heavy chain Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Ferritin heavy chain |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human Ferritin heavy chain |
| Specificity | Ferritin heavy chain Polyclonal Antibody detects endogenous levels of Ferritin heavy chain protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | FTH1 |
| Accession No. | P02794 P09528 P19132 |
| Alternate Names | FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein |
| Description | ferritin heavy chain 1(FTH1) Homo sapiens This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Porphyrin and chlorophyll metabolism, |
| Protein Expression | Brain,Cervix,Colon,Colon adenocarcinoma,Epithelium,Hepatocyte,Liver,Lung,Ovary,Pros |
| Subcellular Localization | cell,nucleus,cytoplasm,mitochondrion,cytosol,intracellular ferritin complex,integral component of membrane,autolysosome,extracellular exosome, |
| Protein Function | catalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.,miscellaneous:In human liver the heavy chain is the major chain.,online information:Ferritin entry,similarity:Belongs to the ferritin family.,similarity:Contains 1 ferritin-like diiron domain.,subunit:Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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