ITT1793
ITT1793
- Catalog: ITT1793
- Gene/Protein: FRS3
- Product Description: Immunotag™ FRS3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | FRS3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Monkey |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FRS3. AA range:191-240 |
| Specificity | FRS3 Polyclonal Antibody detects endogenous levels of FRS3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | FRS3 |
| Accession No. | O43559 Q91WJ0 |
| Alternate Names | FRS3; Fibroblast growth factor receptor substrate 3; FGFR substrate 3; FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2; SNT-2 |
| Description | fibroblast growth factor receptor substrate 3(FRS3) Homo sapiens This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013], |
| Protein Expression | Brain,Placenta, |
| Subcellular Localization | intracellular,plasma membrane, |
| Protein Function | function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.,PTM:Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.,similarity:Contains 1 IRS-type PTB domain.,subunit:Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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