ITT1824
ITT1824
- Catalog: ITT1824
- Gene/Protein: GABRB1
- Product Description: Immunotag™ GABAA Rβ1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GABAA Rβ1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,WB,ELISA |
| Recommended Dilution | WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from GABAA Rβ1, at AA range: 370-450 |
| Specificity | GABAA Rβ1 Polyclonal Antibody detects endogenous levels of GABAA Rβ1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GABRB1 |
| Accession No. | P18505 P50571 P15431 |
| Alternate Names | GABRB1; Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1 |
| Description | gamma-aminobutyric acid type A receptor beta1 subunit(GABRB1) Homo sapiens The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | Brain,Epithelium, |
| Subcellular Localization | nuclear envelope,cytoplasm,plasma membrane,integral component of plasma membrane,integral component of membrane,cell junction,dendrite,chloride channel complex,postsynaptic membrane,GABA-A receptor complex, |
| Protein Function | function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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