ITT1825
ITT1825
- Catalog: ITT1825
- Gene/Protein: GABRB2
- Product Description: Immunotag™ GABAA Rβ2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GABAA Rβ2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the C-terminal region of human GABAA range: Rβ2 |
| Specificity | GABAA Rβ2 Polyclonal Antibody detects endogenous levels of GABAA Rβ2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GABRB2 |
| Accession No. | P47870 P63137 P63138 |
| Alternate Names | GABRB2; Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2 |
| Description | gamma-aminobutyric acid type A receptor beta2 subunit(GABRB2) Homo sapiens The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | Brain, |
| Subcellular Localization | cytosol,plasma membrane,integral component of plasma membrane,integral component of membrane,cell junction,chloride channel complex,synapse,postsynaptic membrane,extracellular exosome,GABA-A receptor complex, |
| Protein Function | function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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