ITT1885
ITT1885
- Catalog: ITT1885
- Gene/Protein: GUCY1A3
- Product Description: Immunotag™ GCS-α-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GCS-α-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human GCS-α-1 |
| Specificity | GCS-α-1 Polyclonal Antibody detects endogenous levels of GCS-α-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GUCY1A3 |
| Accession No. | Q02108 Q9ERL9 P19686 |
| Alternate Names | GUCY1A3; GUC1A3; GUCSA3; GUCY1A1; Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; GCS-alpha-1; Soluble guanylate cyclase large subunit |
| Description | guanylate cyclase 1 soluble subunit alpha(GUCY1A3) Homo sapiens Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012], |
| Cell Pathway/ Category | Purine metabolism,Vascular smooth muscle contraction,Gap junction,Long-term depression, |
| Protein Expression | Brain,Kidney,Prostate, |
| Subcellular Localization | intracellular,plasma membrane,guanylate cyclase complex, soluble,integral component of membrane, |
| Protein Function | catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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