ITT1886
ITT1886
- Catalog: ITT1886
- Gene/Protein: GUCY1B3
- Product Description: Immunotag™ GCS-β-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GCS-β-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from GCS-β-1, at AA range: 10-90 |
| Specificity | GCS-β-1 Polyclonal Antibody detects endogenous levels of GCS-β-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GUCY1B3 |
| Accession No. | Q02153 O54865 P20595 |
| Alternate Names | GUCY1B3; GUC1B3; GUCSB3; GUCY1B1; Guanylate cyclase soluble subunit beta-1; GCS-beta-1; Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunit |
| Description | guanylate cyclase 1 soluble subunit beta(GUCY1B3) Homo sapiens This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014], |
| Cell Pathway/ Category | Purine metabolism,Vascular smooth muscle contraction,Gap junction,Long-term depression, |
| Protein Expression | Brain,Kidney,Lung, |
| Subcellular Localization | intracellular,cytoplasm,plasma membrane,guanylate cyclase complex, soluble,intracellular membrane-bounded organelle, |
| Protein Function | catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,cofactor:Binds 1 or 2 heme groups per heterodimer.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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