ITT1898
ITT1898
- Catalog: ITT1898
- Gene/Protein: GGH
- Product Description: Immunotag™ GGH Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GGH |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GGH. AA range:251-300 |
| Specificity | GGH Polyclonal Antibody detects endogenous levels of GGH protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GGH |
| Accession No. | Q92820 Q9Z0L8 |
| Alternate Names | GGH; Gamma-glutamyl hydrolase; Conjugase; GH; Gamma-Glu-X carboxypeptidase |
| Description | gamma-glutamyl hydrolase(GGH) Homo sapiens This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Folate biosynthesis, |
| Protein Expression | Skin, |
| Subcellular Localization | extracellular space,nucleus,lysosome,vacuole,cytosol,melanosome,extracellular exosome, |
| Protein Function | catalytic activity:Hydrolysis of a gamma-glutamyl bond.,function:Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.,similarity:Belongs to the peptidase C26 family.,similarity:Contains 1 gamma-glutamyl hydrolase domain.,subcellular location:While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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