ITT1927
ITT1927
- Catalog: ITT1927
- Gene/Protein: GRID2
- Product Description: Immunotag™ GluR-δ2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GluR-δ2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from GluR-δ2, at AA range: 800-880 |
| Specificity | GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GRID2 |
| Accession No. | O43424 Q61625 Q63226 |
| Alternate Names | GRID2; GLURD2; Glutamate receptor delta-2 subunit; GluR delta-2 subunit |
| Description | glutamate ionotropic receptor delta type subunit 2(GRID2) Homo sapiens The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction,Long-term depression, |
| Protein Expression | Brain,Cerebellum,PCR rescued clones, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,ionotropic glutamate receptor complex,integral component of membrane,cell junction,dendritic spine,synapse,postsynaptic membrane, |
| Protein Function | domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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