ITT1935
ITT1935
- Catalog: ITT1935
- Gene/Protein: GLRB
- Product Description: Immunotag™ GlyRβ Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GlyRβ |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from GlyRβ, at AA range: 180-260 |
| Specificity | GlyRβ Polyclonal Antibody detects endogenous levels of GlyRβ protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GLRB |
| Accession No. | P48167 P48168 P20781 |
| Alternate Names | GLRB; Glycine receptor subunit beta; Glycine receptor 58 kDa subunit |
| Description | glycine receptor beta(GLRB) Homo sapiens This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | Brain,Hippocampus, |
| Subcellular Localization | cytoplasm,plasma membrane,integral component of plasma membrane,glycine-gated chloride channel complex,cell junction,dendrite,postsynaptic membrane,GABA-ergic synapse, |
| Protein Function | disease:Defects in GLRB are a cause of startle disease (STHE) [MIM:149400]; also known as hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Inheritance can be autosomal dominant or recessive.,function:The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Pentamer composed of alpha and beta subunits. Interacts with GPHN., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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