ITT2047
ITT2047
- Catalog: ITT2047
- Gene/Protein: SYTL4
- Product Description: Immunotag™ Granuphilin Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GranuphIL-in |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Granuphilin, at AA range: 350-430 |
| Specificity | Granuphilin Polyclonal Antibody detects endogenous levels of Granuphilin protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SYTL4 |
| Accession No. | Q96C24 Q9R0Q1 Q8VHQ7 |
| Alternate Names | SYTL4; Synaptotagmin-like protein 4; Exophilin-2; Granuphilin |
| Description | synaptotagmin like 4(SYTL4) Homo sapiens This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010], |
| Protein Expression | Adrenal gland,Endometrium,Epithelium,Platelet,Spinal cord,Testis,Uterus, |
| Subcellular Localization | intracellular,nucleoplasm,cytoplasm,endosome,centrosome,plasma membrane,membrane,extrinsic component of membrane,secretory granule,transport vesicle membrane,exocytic vesicle,presynapse, |
| Protein Function | function:Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RabBD (Rab-binding) domain.,similarity:Contains 2 C2 domains.,subcellular location:Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.,subunit:Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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