ITT2100
ITT2100
- Catalog: ITT2100
- Gene/Protein: HAT1
- Product Description: Immunotag™ HAT1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | HAT1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from HAT1, at AA range: 300-380 |
| Specificity | HAT1 Polyclonal Antibody detects endogenous levels of HAT1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HAT1 |
| Accession No. | O14929 Q8BY71 Q5M939 |
| Alternate Names | HAT1; KAT1; Histone acetyltransferase type B catalytic subunit; Histone acetyltransferase 1 |
| Description | histone acetyltransferase 1(HAT1) Homo sapiens The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009], |
| Cell Pathway/ Category | Protein_Acetylation |
| Protein Expression | Brain,Epithelium,Lung,Testis, |
| Subcellular Localization | chromosome, telomeric region,nuclear chromosome, telomeric region,nuclear chromatin,nucleus,nucleoplasm,cytoplasm,nuclear matrix,intracellular membrane-bounded organelle,protein complex, |
| Protein Function | catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,function:May play a role in telomeric silencing. Acetylates soluble but not nucleosomal H4 at 'Lys-5' and 'Lys-12' and acetylates histone H2A at 'Lys-5'. HAT1 has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.,online information:Histone acetyltransferase entry,similarity:Belongs to the HAT1 family.,subcellular location:Nuclear in S-phase cells and cytoplasmic.,subunit:Heteromer of HAT1 and p46/HAT2 subunits., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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