ITT2120
ITT2120
- Catalog: ITT2120
- Gene/Protein: HDAC8
- Product Description: Immunotag™ HDAC8 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | HDAC8 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Monkey |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from HDAC8, at AA range: 20-100 |
| Specificity | HDAC8 Polyclonal Antibody detects endogenous levels of HDAC8 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HDAC8 |
| Accession No. | Q9BY41 Q8VH37 B1WC68 |
| Alternate Names | HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8 |
| Description | histone deacetylase 8(HDAC8) Homo sapiens Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009], |
| Cell Pathway/ Category | Protein_Acetylation |
| Protein Expression | Colon,Heart,Kidney,Pheochromocytoma,Uterus, |
| Subcellular Localization | histone deacetylase complex,nuclear chromosome,nucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane, |
| Protein Function | catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,miscellaneous:Its activity is inhibited by trichostatin A (TSA) and butyrate, two well known histone deacetylase inhibitors.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subcellular location:Excluded from the nucleoli.,subunit:Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3.,tissue specificity:Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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