ITT2178
ITT2178
- Catalog: ITT2178
- Gene/Protein: HLA-DOB
- Product Description: Immunotag™ HLA-DOβ Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | HLA-DOβ |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HLA-DOB. AA range:1-50 |
| Specificity | HLA-DOβ Polyclonal Antibody detects endogenous levels of HLA-DOβ protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HLA-DOB |
| Accession No. | P13765 |
| Alternate Names | HLA-DOB; HLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB |
| Description | major histocompatibility complex, class II, DO beta(HLA-DOB) Homo sapiens HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Antigen processing and presentation,Intestinal immune network for IgA production,Type I diabetes mellitus,Asthma,Autoimmune thyroid disease,Systemic lupus erythematosus,Allograft rejection,Graft-versus-host disease,Viral myocarditis, |
| Protein Expression | B-cell, |
| Subcellular Localization | intracellular,lysosome,lysosomal membrane,endosome membrane,integral component of membrane,MHC class II protein complex, |
| Protein Function | function:Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule.,polymorphism:The following alleles of DOB are known: DOB*0101, DOB*0102, DOB*0103 and DOB*0104. The sequence shown is that of DOB*0101.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain (DOA) and a beta chain (DOB)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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