ITT2179
ITT2179
- Catalog: ITT2179
- Gene/Protein: HLA-DPA1
- Product Description: Immunotag™ HLA-DPα1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | HLA-DPα1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human HLA-DPα1. |
| Specificity | HLA-DPα1 Polyclonal Antibody detects endogenous levels of HLA-DPα1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HLA-DPA1 |
| Accession No. | P20036 |
| Alternate Names | HLA-DPA1; HLA-DP1A; HLASB; HLA class II histocompatibility antigen; DP alpha 1 chain; DP(W3); DP(W4); HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II DPA1 |
| Description | major histocompatibility complex, class II, DP alpha 1(HLA-DPA1) Homo sapiens HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Antigen processing and presentation,Intestinal immune network for IgA production,Type I diabetes mellitus,Asthma,Autoimmune thyroid disease,Systemic lupus erythematosus,Allograft rejection,Graft-versus-host disease,Viral myocarditis, |
| Protein Expression | Brain,Primary B-Cells,Thymus, |
| Subcellular Localization | Golgi membrane,lysosomal membrane,plasma membrane,integral component of plasma membrane,cell surface,endosome membrane,ER to Golgi transport vesicle membrane,integral component of membrane,transport vesicle membrane, |
| Protein Function | similarity:Belongs to the MHC class II family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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