ITT2310
ITT2310
- Catalog: ITT2310
- Gene/Protein: IL11RA
- Product Description: Immunotag™ IL-11Rα Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | IL-11Rα |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from IL-11Rα . at AA range: 300-380 |
| Specificity | IL-11Rα Polyclonal Antibody detects endogenous levels of IL-11Rα protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | IL11RA |
| Accession No. | Q14626 Q64385 |
| Alternate Names | IL11RA; Interleukin-11 receptor subunit alpha; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA |
| Description | interleukin 11 receptor subunit alpha(IL11RA) Homo sapiens Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Jak_STAT,Hematopoietic cell lineage, |
| Protein Expression | Amygdala,Brain,Muscle,Stomach, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,membrane,integral component of membrane, |
| Protein Function | disease:Increased levels of IL11R are found in prostate carcinoma.,function:Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:On ligand binding, forms a multimer complex with IL6ST/gp130.,tissue specificity:Expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. Also expressed in normal and malignant prostate epithelial cell lines., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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