ITT2376
ITT2376
- Catalog: ITT2376
- Gene/Protein: INTS2
- Product Description: Immunotag™ INTS2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | INTS2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human INTS2. AA range:201-250 |
| Specificity | INTS2 Polyclonal Antibody detects endogenous levels of INTS2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | INTS2 |
| Accession No. | Q9H0H0 Q80UK8 |
| Alternate Names | INTS2; KIAA1287; Integrator complex subunit 2; Int2 |
| Description | integrator complex subunit 2(INTS2) Homo sapiens INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008], |
| Protein Expression | Brain,Testis, |
| Subcellular Localization | intracellular,nucleoplasm,membrane,integral component of membrane,nuclear membrane,integrator complex, |
| Protein Function | caution:It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have shorter N-terminus.,function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the Integrator subunit 2 family.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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