ITT2411
ITT2411
- Catalog: ITT2411
- Gene/Protein: BAIAP2L1
- Product Description: Immunotag™ IRTKS Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | IRTKS |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from IRTKS, at AA range: 80-160 |
| Specificity | IRTKS Polyclonal Antibody detects endogenous levels of IRTKS protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | BAIAP2L1 |
| Accession No. | Q9UHR4 Q9DBJ3 Q3KR97 |
| Alternate Names | BAIAP2L1; IRTKS; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; BAI1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate |
| Description | BAI1 associated protein 2 like 1(BAIAP2L1) Homo sapiens This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal fo |
| Protein Expression | Adrenal gland,Epithelium,Lung,Placenta, |
| Subcellular Localization | nucleoplasm,cytoplasm,cytosol,cytoskeleton,plasma membrane,cell-cell adherens junction,actin cytoskeleton,extracellular exosome, |
| Protein Function | domain:The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation.,function:May function as adapter protein (Potential). Involved in the formation of clusters of actin bundles.,PTM:Phosphorylated on tyrosine in response to insulin.,similarity:Contains 1 IMD (IRSp53/MIM homology) domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with RAC1. Binds to F-actin., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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