ITT2474
ITT2474
- Catalog: ITT2474
- Gene/Protein: KCNJ4
- Product Description: Immunotag™ KIR2.3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | KIR2.3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from KIR23, at AA range: 220-300 |
| Specificity | KIR2.3 Polyclonal Antibody detects endogenous levels of KIR2.3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | KCNJ4 |
| Accession No. | P48050 P52189 P52190 |
| Alternate Names | KCNJ4; IRK3; Inward rectifier potassium channel 4; HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+) channel Kir2.3; IRK-3; Potassium channel; inwardly rectifying subfamily J member 4 |
| Description | potassium voltage-gated channel subfamily J member 4(KCNJ4) Homo sapiens Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Eye,Hippocampus, |
| Subcellular Localization | plasma membrane,voltage-gated potassium channel complex,integral component of membrane,basolateral plasma membrane,cell junction,cytoplasmic vesicle membrane,postsynaptic membrane, |
| Protein Function | domain:The Val/Gly/Ala/Pro stretch may have a functional role in the conductance or permeation properties.,function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Homomultimeric and heteromultimeric association with Kir2.1, resulting in an enhanced G-protein-induced current. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking.,tissue specificity:Heart, skeletal muscle, and several different brain regions including the hippocampus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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