ITT2511
ITT2511
- Catalog: ITT2511
- Gene/Protein: KCNC2
- Product Description: Immunotag™ KV3.2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | KV3.2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from KV32, at AA range: 560-640 |
| Specificity | KV3.2 Polyclonal Antibody detects endogenous levels of KV3.2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | KCNC2 |
| Accession No. | Q96PR1 Q14B80 P22462 |
| Alternate Names | KCNC2; Potassium voltage-gated channel subfamily C member 2; Voltage-gated potassium channel Kv3.2 |
| Description | potassium voltage-gated channel subfamily C member 2(KCNC2) Homo sapiens The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012], |
| Protein Expression | Amygdala,Brain, |
| Subcellular Localization | intracellular,plasma membrane,integral component of plasma membrane,voltage-gated potassium channel complex,membrane,integral component of membrane,basolateral plasma membrane,apical plasma membrane,cell junction,axon, |
| Protein Function | domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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