ITT2541
ITT2541
- Catalog: ITT2541
- Gene/Protein: LPHN1
- Product Description: Immunotag™ Latrophilin-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | LatrophIL-in-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IF,ELISA |
| Recommended Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Latrophilin-1, at AA range: 530-610 |
| Specificity | Latrophilin-1 Polyclonal Antibody detects endogenous levels of Latrophilin-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | LPHN1 |
| Accession No. | O94910 Q80TR1 O88917 |
| Alternate Names | LPHN1; KIAA0821; LEC2; Latrophilin-1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2 |
| Description | adhesion G protein-coupled receptor L1(ADGRL1) Homo sapiens This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008], |
| Protein Expression | Brain,Lung,T-cell,Whole embryo, |
| Subcellular Localization | intracellular,plasma membrane,membrane,integral component of membrane,cell junction,axon,growth cone,presynaptic membrane,neuron projection,synapse,presynapse, |
| Protein Function | domain:The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.,function:Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 olfactomedin-like domain.,similarity:Contains 1 SUEL-type lectin domain.,subunit:Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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