ITT2568
ITT2568
- Catalog: ITT2568
- Gene/Protein: PPFIBP1
- Product Description: Immunotag™ Liprin β1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Liprin β1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LIPB1. AA range:300-349 |
| Specificity | Liprin β1 Polyclonal Antibody detects endogenous levels of Liprin β1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PPFIBP1 |
| Accession No. | Q86W92 Q8C8U0 |
| Alternate Names | PPFIBP1; KIAA1230; Liprin-beta-1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; PTPRF-interacting protein-binding protein 1; hSGT2 |
| Description | PPFIA binding protein 1(PPFIBP1) Homo sapiens The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Epithelium,Skin, |
| Subcellular Localization | plasma membrane,cell-cell adherens junction,focal adhesion, |
| Protein Function | domain:The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4.,function:May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.,similarity:Belongs to the liprin family. Liprin-beta subfamily.,similarity:Contains 3 SAM (sterile alpha motif) domains.,subunit:Forms homodimers and heterodimers. Interacts with S100A4 in a calcium-dependent mode.,tissue specificity:Widely expressed. Absent in liver., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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