ITT2601
ITT2601
- Catalog: ITT2601
- Gene/Protein: LTB
- Product Description: Immunotag™ LT-β Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | LT-β |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNFC. AA range:181-230 |
| Specificity | LT-β Polyclonal Antibody detects endogenous levels of LT-β protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | LTB |
| Accession No. | Q06643 P41155 |
| Alternate Names | LTB; TNFC; TNFSF3; Lymphotoxin-beta; LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3 |
| Description | lymphotoxin beta(LTB) Homo sapiens Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction, |
| Protein Expression | Colon,Peripheral blood leukocyte,Spleen,T-cell, |
| Subcellular Localization | extracellular space,plasma membrane,integral component of membrane, |
| Protein Function | function:Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.,similarity:Belongs to the tumor necrosis factor family.,subunit:Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.,tissue specificity:Spleen and thymus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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