ITT2611
ITT2611
- Catalog: ITT2611
- Gene/Protein: CHRM1
- Product Description: Immunotag™ mAChR M1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | mAChR M1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from mAChR M1, at AA range: 270-350 |
| Specificity | mAChR M1 Polyclonal Antibody detects endogenous levels of mAChR M1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CHRM1 |
| Accession No. | P11229 P12657 P08482 |
| Alternate Names | CHRM1; Muscarinic acetylcholine receptor M1 |
| Description | cholinergic receptor muscarinic 1(CHRM1) Homo sapiens The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Calcium,Neuroactive ligand-receptor interaction,Regulates Actin and Cytoskeleton, |
| Protein Expression | Amygdala,Brain, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,postsynaptic density,membrane,cell junction,dendrite,asymmetric synapse,axon terminus,synapse,postsynaptic membrane, |
| Protein Function | function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with GPRASP2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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