ITT2634
ITT2634
- Catalog: ITT2634
- Gene/Protein: MFNG
- Product Description: Immunotag™ Manic Fringe Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Manic Fringe |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MFNG. AA range:61-110 |
| Specificity | Manic Fringe Polyclonal Antibody detects endogenous levels of Manic Fringe protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MFNG |
| Accession No. | O00587 O09008 |
| Alternate Names | MFNG; Beta-1; 3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| Description | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase(MFNG) Homo sapiens This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009], |
| Cell Pathway/ Category | Notch, |
| Protein Expression | Lymph, |
| Subcellular Localization | extracellular space,membrane,integral component of Golgi membrane, |
| Protein Function | catalytic activity:Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.,function:Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.,online information:Beta-1,3-N-acetylglucosaminyltransferase manic fringe,online information:GlycoGene database,similarity:Belongs to the glycosyltransferase 31 family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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