ITT2727
ITT2727
- Catalog: ITT2727
- Gene/Protein: MTNR1B
- Product Description: Immunotag™ MEL-1B-R Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MEL-1B-R |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MTR1B. AA range:301-350 |
| Specificity | MEL-1B-R Polyclonal Antibody detects endogenous levels of MEL-1B-R protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MTNR1B |
| Accession No. | P49286 Q8CIQ6 |
| Alternate Names | MTNR1B; Melatonin receptor type 1B; Mel-1B-R; Mel1b receptor |
| Description | melatonin receptor 1B(MTNR1B) Homo sapiens This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | Ovary,Retina, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,integral component of membrane, |
| Protein Function | function:High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.,online information:Melatonin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in retina and less in brain and hippocampus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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