ITT2783
ITT2783
- Catalog: ITT2783
- Gene/Protein: MAP3K9
- Product Description: Immunotag™ MLK1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MLK1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAP3K9. AA range:561-610 |
| Specificity | MLK1 Polyclonal Antibody detects endogenous levels of MLK1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MAP3K9 |
| Accession No. | P80192 Q3U1V8 |
| Alternate Names | MAP3K9; MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1 |
| Description | MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 include retroperitoneal neuroblastoma. Among its related pathways are MAP Kinase Signaling andTGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KSR1. |
| Cell Pathway/ Category | Regulation of Actin Dynamics, SAPK_JNK, Stem cell pathway, B_Cell_Antigen |
| Protein Expression | Colon epithelium,Spleen, |
| Subcellular Localization | intracellular,integral component of membrane, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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